Bibliografía

Plasma Rico en Plaquetas (PRP)

  • Pourcho AM, Smith J, Wisniewski SJ, Sellon JL
    Intraarticular Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis: Review and Recommendations.
    American Journal of Physical Medicine and Rehabilitation, May 29, 2014
  • Jennifer Davis. Platelet-rich Plasma Therapy: What You Should Know. www.ArthritisToday.org
  • Michael Scarpone, DO; David Rabago, MD; Edward Snell, MD; Patrick DeMeo, MD; Kristine Ruppert, Dr PH; Perry Pritchard, PT, ATC; Gennie Arbogast, ATC; John
  • Wilson, MD, MS; John F. Balzano, MD
  • Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study. Global Adv Health Med. ;0(ja):2-2
  • Vora A, Borg-Stein J, Nguyen RT. Regenerative injection therapy for osteoarthritis: fundamental concepts and evidence-based review
  • American Academy of Physical Medicine and Rehabilitation. PM R. 2012 May;4(5 Suppl):S104-9
  • Kenneth Mautner, Gerard Malanga & Ricardo Colberg. Optimization of ingredients, procedures and rehabilitation for platelet-rich plasma injections for chronic tendinopathy. Future Medicine, 2011
  • Alsousou, A. Ali, K. Willett et al. The role of platelet-rich plasma in tissue regeneration. Informa Healthcare May 30, 2012
  • Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA. Platelet-Rich Plasma: A Milieu of Bioactive Factors. Arthroscopy 2012 Jan 25.
  • Rosalyn T Nguyen MD, Joanne Borg-Stein MD, Kelly McInnis DO. Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach. PM&R; 2011 Mar; 3(3): 226-250.
  • Kenneth S Lee, John J Wilson, David P Rabago, Geoffrey S Baer, Jon A Jacobson, Camilo G Borrero. Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future? AJR Am J Roentgenol. 2011 Mar;196(3):628-36.
  • Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74.
  • Tate K MD, Crane D. Platelet Rich Plasma Grafts in Musculoskeletal Medicine. Journal of Prolotherapy. 2010 May; 2(2): 371-376.
  • Crane D, Everts P. Platelet Rich Plasma (PRP) Matrix Grafts. Practical Pain Management2008:8 (1):11-26.
  • Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA. Platelet-rich plasma: current concepts and application in sports medicine. J Am Acad Orthop Surg. 2009 Oct;17(10):602-8.
  • Sánchez M, Anitua E, Orive G, Mujika I, Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009;39(5):345-54
  • Molloy T, Wang Y, Murrell G. 2003. The Roles of Growth Factors in Tendon and Ligament Healing. Sports Med. 33(5):381-394

 

Estudios en humanos

TENDONES / LIGAMENTOS

  • Jason L. Dragoo, MD, Hillary J. Braun, BA, Jennah L. Durham, BA, Bethany A. Ridley, BA, Justin I. Odegaard, MD, Richard Luong, BVSc DACVP and Steven P. Arnoczky, DVM
    Comparison of the Acute Inflammatory Response of Two Commercial Platelet-Rich Plasma Systems in Healthy Rabbit Tendons
    Am J Sports Med. 2012 April 10.

DE HOMBRO

  • Steven Sampson, DO
    Use of Platelet Rich Plasma for the Treatment of Bicipital Tendinopathy in Spinal Cord Injury: A Pilot Study. International Scientific Tendinopathy
    Symposium (ISTS). Vancouver, Canada. Sept 30, 2012
  • V M Ibrahim, S L Groah, A Libin, I H Ljungberg, D Aufiero, K Patel, S Sampson. Use of Platelet Rich Plasma For The Treatment Of Bicipital Tendinopathy In Spinal Cord Injury: A Pilot Study. Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.39.
  • Maureen Leahy. PRP May Be Effective Treatment for RCT. American Academy of Orthopaedic Surgeons. 2013 Annual Meeting News February 19 – 23, 2013.
  • Muto T, Kokubu T, Mifune Y, Sakata R, Nagura I, Nishimoto H, Harada Y, Nishida K, Kuroda R, Kurosaka M.. Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide. J Orthop Res. 2012 Dec 31. doi: 10.1002/jor.22301.
  • Rha DW, Park GY, Kim YK, Kim MT, Lee SC.
    Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial.
    Clin Rehabil. 2012 Oct 3. [Epub ahead of print] PMID: 23035005 [PubMed – as supplied by publisher]
  • Moon YL, Ha SH, Lee YK, Park YK.
    Comparative Studies of Platelet-Rich Plasma (PRP) and Prolotherapy for Proximal Biceps Tendinitis.
    Clin Should Elbow. 2011 Dec;14(2):153-158
  • Jo CH, Kim JE, Yoon KS, Shin S.
    Platelet-Rich Plasma Stimulates Cell Proliferation and Enhances Matrix Gene Expression and Synthesis in Tenocytes From Human Rotator Cuff Tendons With Degenerative Tears.
    Am J Sports Med. 2012 Feb 23.
  • Nickolas Garbis MD, Anthony A. Romeo MD, Geoffrey Van Thiel MD, MBA, Neil Ghodadra MD, Matthew T. Provencher MD, Brian J. Cole MD, MBA, Nikhil Verma MD
    Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Shoulder
    Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 165-169.

DE CODO

  • Allan K. Mishra, MD, Nebojsa V. Skrepnik, MD, Scott G. Edwards, MD, Grant L. Jones, MD, Steve Sampson, DO, Doug A. Vermillion, MD, Matthew L. Ramsey, MD, David Karli, Vail, Arthur C. Rettig, MD.
  • Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Chronic Tennis Elbow
    The Orthobiologic Institute, March, 2013.
  • Allan K. Mishra, MD, Nebojsa V. Skrepnik, MD, PHD, Scott G. Edwards, MD, Grant L. Jones, MD, Steven Sampson, DO,
    Platelet-Rich Plasma Significantly Improves Clinical Outcomes in Patients With Chronic Tennis Elbow: A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients
    Am J Sports Med July 3, 2013
  • Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, Sayeed YA, Smith J
    Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection
    PM R 2011 Oct; 3(10):900-11.
  • Allan Mishra MD, Taco Gosens MD, PhD
    Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Elbow
    Operative Techniques in Sports Medicine, 2011
  • Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, Sayeed YA, Smith J.
    Treatment of Chronic Tendinopathy with Ultrasound-Guided Needle Tenotomy and Platelet-Rich Plasma Injection
    PM R. 2011 Aug 25. Epub ahead of print
  • Taco Gosens MD/PhD, Joost C Peerbooms MD, Wilbert van Laar, Brenda L den Oudsten PhD.
    Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-Year Follow-Up
    Am J Sports Med; 2011 Mar.
  • Keith S Hechtman MD, John W Uribe MD, Angie Botto-Vandemen PhD, Gary M Kiebzak PhD
    Platelet-rich Plasma Injection Reduces Pain in Patients With Recalcitrant Epicondylitis
    Orthopedics, February 2011.
  • Rabago D, Best TM, Zgierska AE, Zeisig E, Ryan M, Crane D
    A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.
    Br J Sports Med; 2009 Jul;43(7):471-81
  • Alsousou J, Thompson M, Hulley P, Noble A, Willett K
    The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
    J Bone Joint Surg Br; 2009 Aug;91(8):987-96
  • Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA
    Platelet-rich plasma: current concepts and application in sports medicine.
    J Am Acad Orthop Surg; 2009 Oct;17(10):602-8
  • Peerbooms, J. C., Sluimer, J., Bruijn, D. J., Gosens, T.
    Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
    Am J Sports Med 38: 255-262
  • Mishra A, Pavelko T.
    Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
    Am J Sports Med. 2006 Nov;34(11):1774-8.
  • Edwards SG, Calandruccio JH.
    Autologous blood injections for refractory lateral epicondylitis
    Am J Hand Surg. 2003;28(2):272–8.

DE RODILLA

  • De Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ.
    Platelet-Rich Plasma Added to the Patellar Tendon Harvest Site During Anterior Cruciate Ligament Reconstruction Enhanced Healing
    Am J Sports Med. 2012 Jun;40(6):1282-8.
  • Podesta L, Crow SA, Volkmer D, Bert T, Yocum LA.
    Treatment of Partial Ulnar Collateral Ligament Tears in the Elbow With Platelet-Rich Plasma.
    Am J Sports Med. 2013 May 10
  • Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J.
    Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis.
    Clin J Sport Med. 2012 Dec 12.
  • Giuseppe Filardo, Elizaveta Kon, Stefano Della Villa, Ferruccio Vincentelli, Pier Maria Fornasari and Maurilio Marcacci
    Use of platelet-rich plasma for the treatment of refractory jumper’s knee
    International Orthopaedics; 31 July 2009; Vol 24, No 6; 909-915
  • Elizaveta Kon, Giuseppe Filardo, Marco Delcogliano, Mirco Lo Presti, Alessandro Russo, Alice Bondi, Alessandro Di Martino, Annarita Cenacchi, Pier Maria Fornasari, Maurilio Marcacci
    Platelet-rich plasma: New clinical application: A pilot study for treatment of jumper’s knee
    International Journal of the Care of the Injured; 2009 June; 40(6): 509-603
  • Kelly L. Scollon-Grieve, MD, Gerard A. Malanga, MD
    Platelet-Rich Plasma Injection for Partial Patellar Tendon Tear in a High School Athlete: A Case Presentation
    American Academy of Physical Medicine and Rehabilitation, Vol. 3, 391-395, April 2011.

DE TOBILLO/PIE

  • Monto, Raymond R MD
    Platelet Rich Plasma and Plantar Fasciitis
    Sports Medicine and Arthroscopy Review. Dec 2013
  • Kumar V, Millar T, Murphy PN, Clough T. The treatment of intractable plantar fasciitis with platelet-rich plasma injection. Foot (Edinb). 2013 Jul 29.
  • Kim E, Lee JH.
    Autologous Platelet-Rich Plasma Versus Dextrose Prolotherapy for the Treatment of Chronic Recalcitrant Plantar Fasciitis.
    PM R. 2013 Jul 19.
  • Martinelli N, et al.
    Platelet-rich plasma injections for chronic plantar fasciitis.
    Int Orthop. 2012 Dec 19.
  • Monto RR.
    Platelet rich plasma treatment for chronic achilles tendinosis.
    Foot Ankle Int. 2012 May;33(5):379-85.
  • Ragab EM, Othman AM.
    Platelets rich plasma for treatment of chronic plantar fasciitis.
    Arch Orthop Trauma Surg. 2012 May 4
  • Monto, R.
    Platelet-Rich Rich Plasma is More Effective than Cortisone for Chronic Severe Plantar Fasciitis
    2012 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.
  • Xiaofeng Jia MD, PhD, Paul G. Peters MD, Lew Schon MD
    The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions
    Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 177-184.
  • teven Sampson, Danielle Aufiero, Michael Meng, Anthony Bledin, Terry Gillette, Mona Zall
    Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
    International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.
  • Wiegerinck JI, Reilingh ML, de Jonge MC, van Dijk CN, Kerkhoffs GM
    Injection Techniques of Platelet-Rich Plasma Into and Around the Achilles Tendon: A Cadaveric Study
    Am J Sports Med, April 19 2011.
  • Gaweda K.
    Treatment of Achilles Tendinopathy with Platelet RichPlasma
    International Journal of Sports Med, June 2010.
  • P Robert J. de Vos et al.
    Platelet-Rich Plasma Injection for Chronic Achilles Tendinopathy: A Randomized Controlled Study
    JAMA 2010, 3003(2): 144-149.
  • Monto, R.
    Platelet Rich Plasma (PRP) Effectively Treats Chronic Achilles Tendinosis
    2010 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.
  • O’ Malley M.
    Platelet-rich plasma (PRP) in managing Achilles tendinosis
    2010 Annual American Orthopaedic Foot & Ankle Society (AOFAS) Meeting.
  • Filardo, G, Lo Presti M, Kon E, Marcacci M. 2010.
    Nonoperative Biological Treatment Approach for partial Achilles Tendon Lesion
    Orthopedics 1;33(2):120-3.
  • Barrett S, Erredge S.
    Growth factors for chronic plantar fasciitis
    Podiatry Today 2004;17:37.

DE ISQUIOTIBIALES

  • Hamid M, Ali M, Yusof A, George J.
    Platelet-Rich Plasma (PRP): an adjuvant to hasten hamstring muscle recovery. A randomized controlled trial protocol (ISCRTN66528592)
    BioMedCentral 2012

MÚSCULO

  • Bernuzzi G, Petraglia F, Pedrini MF, De Filippo M, Pogliacomi F, Verdano MA, Costantino C.
    Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection.
    PM 2013 Jul 3
  • Borrione P, Grasso L, Chierto E, Geuna S, Racca S, Abbadessa G, Ronchi G, Faiola F, Di Gianfrancesco A, Pigozzi F.
    Experimental model for the study of the effects of platelet-rich plasma on the early phases of muscle healing.
    PM 2013 Jun 19
  • Gino Bernuzzi, Federica Petraglia, Martina Francesca Pedrini, Massimo De Filippo, Francesco Pogliacomi, Michele Arcangelo Verdano, Cosimo Costantino
    Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection
    Society on Transfusion Medicine and Immunohaematology (SIMTI) Published online: 03/07/2013
  • Hector A. Mejia MD, James P. Bradley MD
    The Effects of Platelet-Rich Plasma on Muscle: Basic Science and Clinical Application
    Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 149-153.
  • Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM
    Use of autologous platelet-rich plasma to treat muscle strain injuries.
    Am J Sports Med; 2009 Jun;37(6):1135-42
  • Nikolidakis D, Jansen JA
    The biology of platelet-rich plasma and its application in oral surgery: literature review.
    Tissue Eng Part B Rev; 2008 Sep;14(3):249-58
  • Borrione, Paolo MD; Gianfrancesco, Alessia Di PharmD; Pereira, Maria Teresa MD; Pigozzi, Fabio MD
    Platelet-Rich Plasma in Muscle Healing
    American Journal of Physical Medicine & Rehabilitation: October 2010 – Volume 89 – Issue 10 – pp 854-861.
  • Mishra A, Woodall Jr. J, Vieira A. 2009.
    Treatment of Tendon and Muscle Using Platelet-Rich Plasma
    Clin Sports Med 28(1): 113-25.
  • Carpenter, T et al.
    Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains
    Int J Sports Med, 2004. 25:589-594.
  • Hammond, JW et al.
    Use of autologous platelet-rich plasma to treat muscle strain injuries
    American Journal of Sports Med, 2009. 37 (6): 1135-1142.

 DE RODILLA

  • Pourcho AM, Smith J, Wisniewski SJ, Sellon JL
    Intraarticular Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis: Review and Recommendations.
    American Journal of Physical Medicine and Rehabilitation, May 29, 2014
  • Alberto Gobbi, MD, Georgios Karnatzikos
    The Use of Platelet-Rich Plasma in Degenerative Lesions of the Knee: Results at Two-year Follow Up
    OASIS, Mar 20, 2013.
  • Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J.
    Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis.
    PMID: 23238250 [PubMed – as supplied by publisher]
  • Sandeep Patel, Mandeep S. Dhillon, Sameer Aggarwal, Neelam Marwaha, and Ashish Jain
    Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
    AJSM PreView, published on January 8, 2013 as doi:10.1177/0363546512471299
  • Ana Wang-Saegus, Ramón Cugat, Oscar Ares, Roberto Seijas, Xavier Cuscó, Montserrat Garcia-Balletbó
    Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
    Arch Orthop Trauma Surg, Springer-Verlag 2010
  • Antonio Frizziero · Erika Giannotti · Claudio Ferraro · Stefano Masiero
    Platelet rich plasma intra-articular injections: a new therapeutic strategy for the treatment of knee osteoarthritis in sport rehabilitation.
    A systematic review
    Sport Sci Health (2012) 8:15–22
  • Alberto Gobbi, MD, Georgios Karnatzikos, MD, Vivek Mahajan, MD, and Somanna Malchira, MD
    Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
    Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
  • Timea Spakova, PhD, Jan Rosocha, DVM, PhD, Marek Lacko, MD, Denisa Harvanova, PhD, Ahmed Gharaibeh, M
    Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid
    American Journal of Physical Medicine & Rehabilitation 0894-9115/12/9104-0000/0
  • Napolitano M, Matera S, Bossio M, Crescibene A, Costabile E, Almolla J, Almolla H, Togo F, Giannuzzi C, Guido G
    Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
    Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11. [Epub ahead of print]
  • Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M
    Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis
    Arthroscopy. 2011 Aug 8. (Epub ahead of print)
  • Biomechanics Laboratory-III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy.
  • Park SI, Lee HR, Kim S, Ahn MW, Do SH. Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures Mol Cell Biochem. 2011 Sep 29. (Epub ahead of print)
  • Department of Orthopedic Surgery, College of Medicine, Yeungnam University, Daegu, 705-717, Korea.
  • Lisa A. Fortier DVM, PhD, Catherine H. Hackett DVM, PhD, Brian J. Cole MD, MBA
    The Effects of Platelet-Rich Plasma on Cartilage: Basic Science and Clinical Application
    Platelet-rich plasma (PRP) is emerging as a biological therapy for the treatment of cartilage injuries and for intra-articular application to address knee pain. Basic science studies indicate that PRP stimulates cell proliferation and the production of cartilage matrix by chondrocytes and …
    Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 154-159.
  • Gerben M. van Buul, MD, Wendy L.M. Koevoet, BSc, Nicole Kops, BSc, P. Koen Bos, MD, PhD, Jan A.N. Verhaar, MD, PhD, Harrie Weinans, PhD, Monique R. Bernsen, PhD, Gerjo J.V.M. van Osch, PhD
    Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes
    The American Journal of Sports Medicine; August 19, 2011
  • Steven E. Sampson DO, Marty Reed MD, Holly Silvers MPT, Michael Meng DC, Bert Mandelbaum MD.
    Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
    The American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online Dec 2010 print. 961-969
  • Ana Wang-Saegusa, Ramón Cugat, Oscar Ares, Roberto Seijas, Xavier Cuscó and Montserrat Garcia-Balletbó.
    Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
    Archives of Orthopaedic and Trauma Surgery, Volume 131, Number 3, 311-317, DOI: 10.1007/s00402-010-1167-3.
  • Hunziker EB, Driesang IM, Morris EA. Clinical orthopaedics and related research.
    Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
    Clin Orthop Relat Res. 2001;391(Suppl):S171–81.
  • Nakagawa K, Sasho T, Arai M, Kitahara S, Ogino S, Wada Y, et al.
    Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes
    Chiba and Ichihara, Japan. Electronic poster presentation P181. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.
  • Kon E, Filardo G, Presti ML, Delcogliano M, Iacono F, Montaperto C, et al.
    Utilization of platelet-derived growth factors for the treatment of cartilage degenerative pathology
    Bologna, Italy. Electronic poster presentation 29.3. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.
  • Anitua E, Sanchez M, Nurden AT, Zalduendo MM, De La Fuente M, Azofra J, et al.
    Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients
    Rheumatology.
    2007;46(12):1769–72.
  • Kon E, Buda R, Mandelbaum B, Filardo G, Timoncini A, Delcogliano M, Fornasari P, Giannini S, Marcacci M.
    PRP intra-articular injection versus viscosupplementation as treatments for early osteoarthritis
    Podium Presentation, # 685. American Academy of Orthopaedic Surgeons, New
  • Orleans LA. March 12, 2010. Platelet-rich plasma – A promising cell carrier for micro-invasive articular cartilage repair. [Journal Article, Research Support, Non-U.S. Gov’t]. Med Hypotheses 2009 Apr; 72(4):455-7.
  • Sun, Y et al.
    The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
    International Orthopaedics, 2010.
    34:589-597.
  • Elizaveta Kon, Roberto Bnda, Ginseppe Filardo, Alessandro Di Martino, Antonio Timoncini, Annarita Cenacchi, Pier Maria Fornasari, Sandro Giannini, Maurilio Marcacci.
    Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions
    Knee Surg Sports Traumatol Arthrosc. Sept 2009: 0940-8.
  • Nathan Wei.
    Tissue Engineering with Platelet-Rich Plasma and Stem Cells: New Frontier In Rheumatology
    The Journal of Musculoskeletal Medicine. July 2009.
  • Sanchez M, Azofra J, Anitua E, Andia I, Padilla S, Santisteban J, Mujika I (2003).
    Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
    Med Sci Sports Exerc 35:1648-1652.
  • Berghoff W, Pietrzak W, Rhodes R.
    Platelet-rich plasma application during closure following total knee arthroplasty
    Orthopedics. 2006;29(7):590–8.
  • Gardner MJ, Demetrakopoulos D, Klepchick P, Mooar P.
    The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty: an analysis of the haemoglobin, narcotic requirement and range of motion
    Int Orthop. 2006;31:309–13.
  • Everts P, Devilee R, Mahoney C, Eeftinck-Schattenenkerk M, Knape J, Van Zundert A.
    Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty
    Acta Anaesthesiol Scand. 2006;50:593–9.
  • Sanchez M., Fiz N., Azofra J., Usabiaga J., Aduriz Recalde E., Garcia Gutierrez A., Albillos J., (…), Anitua E.
    A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis
    (2012) Arthroscopy – Journal of Arthroscopic and Related Surgery, 28 (8), pp. 1070-1078.

DE CADERA

  • Wetzel RJ, Patel RM, Terry MA.
    Platelet-rich Plasma as an Effective Treatment for Proximal Hamstring Injuries.
    Orthopedics. 2013 Jan 1;36(1):e64-70. doi: 10.3928/01477447-20121217-20.
  • Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
    Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
    Knee Surg Sports Traumatol Arthrosc.
  • Mikel Sánchez, Jorge Guadilla, Nicolás Fiz, Isabel Andia
    Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip
    Rheumatology (2011) doi: 10.1093/rheumatology/ker303 First published online: November 10, 2011.

GENERAL

  • Alberto Gobbi, MD, Georgios Karnatzikos, MD, Vivek Mahajan, MD, and Somanna Malchira, MD
    Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
    Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
  • Timea Spakova, PhD, Jan Rosocha, DVM, PhD, Marek Lacko, MD, Denisa Harvanova, PhD, Ahmed Gharaibeh, M
    Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid
    American Journal of Physical Medicine & Rehabilitation 0894-9115/12/9104-0000/0
  • Napolitano M, Matera S, Bossio M, Crescibene A, Costabile E, Almolla J, Almolla H, Togo F, Giannuzzi C, Guido G
    Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
    Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11. [Epub ahead of print]

COLUMNA

  • Hu X, Wang C, Rui Y.
    An experimental study on effect of autologous platelet-rich plasma on treatment of early intervertebral disc degeneration.
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Aug;26(8):977-83. Chinese.
    PMID: 23012935 [PubMed]
  • Schroeder, Josh; Grad, Sibylle; Verrier, Sophie; Peroglio, Marianna; Kaplan, Leon; Hasharoni, Amir; Barzilay, Yair; Liebergall, Meir; Richards, Geoff; Alini, Mauro
    Proliferation of Annulus Fibrosus Cells in Platelet Rich Plasma A Natural 3D Scaffold: An in Vitro Study: Gp8
    Spine: Affiliated Society Meeting Abstracts . Supplement 1, October 2011.
  • Adam D. Weglein
    Focused Review: Current Trends in Platelet-Rich Plasma Injection Treatments
    Journal of Neurosurgical Review, Vol 1 (2011).

NERVIOS

Estudios en animal

  • Shuji Obata, Koji Akeda, Takao Imanishi, Koichi Masuda, Won Bae, Ryo Morimoto, Yumiko Asanuma, Yuichi Kasai, Atsumasa Uchida, Akihiro Sudo.
    Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study 
    Arthritis Research & Therapy 2012, 14:R241
  • Kwon DR, Park GY, Lee SU.
    The effects of intra-articular platelet-rich plasma injection according to the severity of collagenase-induced knee osteoarthritis in a rabbit model.
    Ann Rehabil Med. 2012 Aug;36(4):458-65. Epub 2012 Aug 27.
    PMID: 22977770
  • Geng Z, Wang C, Zhou H
    Effect of platelet-rich plasma on tendon healing
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Mar 2011; 25(3):344-8.
  • Harris, N. Lindsay, MD; Purnell, Mark L., MD; Huffer, William E., MD; Larson, Andrew I.
    The Effect of Platelet-Rich Plasma (PRP) on Normal Soft Tissues in the Rabbit BSME
    Phinney, Shawn, MA; Von Stade, Eleanor F., MD. Aspen Orthopaedics Associates and Aspen Sports Medicine Foundation (AMSF).
  • Wu W, Chen F, Liu Y, Ma Q, Mao T
    Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. [Journal Article, Research Support, Non-U.S. Gov’t] J Oral Maxillofac Surg 2007 Oct; 65(10):1951-7.
  • Bir SC, Esaki J, Marui A, Yamahara K, Tsubota H, Ikeda T, Sakata R
    Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse. [Comparative Study, In Vitro, Journal Article] J Vasc Surg 2009 Oct; 50(4):870-879.e2.
  • Aspenberg P, Virchenko O. 2004.
    Platelet concentrate injection improves Achilles tendon repair in rats
    Acta Orthop Scand 75(1):93-9.
  • Taylor M, Norman T, Clovis N, Blaha D.
    The response of rabbit patellar tendons after autologous blood injection
    Med Sci Sports Exerc. 2002;34(1):70–3.
  • Carpenter, T, et al.
    Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model
    Int J Sports Med, 2004. 25:1-6.

 FISIOLOGÍA DEL PRP

  • Eppley BL, Woodell JE, Higgins J
    Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
    Plast Reconstr Surg. 2004 Nov;114(6):1502-8.
  • Wang P, Qu Y, Man Y
    Platelet-rich plasma as a scaffold for injectable soft-tissue augmentation.
    Cytotherapy 2010 May 21.

 REHABILITACIÓN POST PRP

  • Van Ark M, Van den Akker-Scheek I, Meijer LT, Zwerver J.
    An exercise-based physical therapy program for patients with patellar tendinopathy after platelet-rich plasma injection.
    Phys Ther Sport. 2012 Sep 22
    PMID: 23010772 [PubMed]

Proloterapia

Artrosis

 

  • The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review Hassan, et al. British Medical Bulletin, 2017, 122:91–108
  • Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial
    Sit, R. Keung Wu, D. Rabago, K. D. Reeves, D. Chan, B. Yip, V. Chung and S. Wong, The Annals of Family Medicine May 2020, 18 (3) 235-242
  • Hypertonic Dextrose Stimulates Chondrogenic Cells to Deposit Collagen and Proliferate E. Johnston , Y. Kou , J. Junge , L. Chen , A. Kochan , M. Johnston , D. Rabago Cartilage. Vol 13, Issue 2_suppl (2021)
  • Dextrose prolotherapy for knee osteoarthritis: A randomized controlled trial.RabagoD,PattersonJJ,MundtM,Kijowski,R,GrettieJ, Segal N, Zgierska AE; Ann Fam Med; 11(3):229-237; 2013
  • The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Rahimzadeh P, Imani F, Faiz SHR, Entezary SR, Zamanabadi MN, Alebouyeh MR.. Clin Interv Aging 2018;13:73-9.
  • Efficacy of intra-articular hypertonic dextrose (prolotherapy) for knee osteoarthritis: A randomized controlled trial . Sit RWS, Wu RWK, Rabago D, Reeves KD, Chan DCC, Yip BHK, Chung VCH, Wong SYS.. The Annals of Family Medicine 2020;18:235-42.
  • The effects of dextrose prolotherapy in symptomatic knee osteoarthritis: A randomized controlled study . Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E.. J Altern Complement Med 2020;26:409-17.
  • Physical therapy, intra-articular dextrose prolotherapy, botulinum neurotoxin, and hyaluronic acid for knee osteoarthritis: randomized clinical trial. Rezasoltani Z, Azizi S, Najafi S, Sanati E, Dadarkhah A, Abdorrazaghi F. Int J Rehabil Res 2020;43:219-27.
  • Effect of dextrose prolotherapy, platelet rich plasma and autologous conditioned serum on knee osteoarthritis: A randomized clinical trial . Pishgahi A, Abolhasan R, Shakouri SK, Soltani-Zangbar MS, Dareshiri S, Ranjbar Kiyakalayeh S, Khoeilar A, Zamani M, Motavalli Khiavi F, Pourabbas Kheiraddin B, Mehdizadeh A, Yousefi M.. Iran J Allergy Asthma Immunol 2020;19:243-52

TENDONES Y FASCIAS

  • Effectiveness and safety of prolotherapy injections for management of lower limb tendinopathy and fasciopathy: a systematic review Lane Anderson et al. J of Foot and Ankle Research, vol 8, Article number: 57 (2015)

DOLOR LUMBAR

  • Cusi et al. (2008); The use of prolotherapy in the SI joint; BJSM; PMID: 18400878
  • Khan et al. (2008) Dextrose prolotherapy for recalcitant coccygodynia; J Orthopedic Surg; 16:27-29
  • Hooper et al. (2004) ; Hooper, R. A. and Ding, M. Retrospective case series on patients with chronic spinal pain treated with dextrose prolotherapy. J Altern Complem Med 10, 670-674

TENDINOPATIA MANGUITO ROTADOR – HOMBRO

  • Cole BJ, Lam P, Hackett L, Murrell GAC. Ultrasound-guided injections for supraspinatus tendinopathy: corticosteroid versus glucose prolotherapy – a randomized controlled clinical trial. Shoulder Elbow 2018;10:170-8.
  • Lin CL, Huang CC, Huang WS. Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder: a randomized placebo-controlled trial Eur J Phys Rehabil Med 2019;55:480-7.
  • George J, Li SC, Jaafar Z, Hamid MSA. Comparative effectiveness of ultrasound-guided intratendinous prolotherapy injection with conventional treatment to treat focal supraspinatus tendinosis. Scientifica 2018;Jul 2:2018:4384159.
  • Chang YJ, Chang FH, Hou PH, Tseng KH, Lin YN. Effects of hyperosmolar dextrose injection in patients with rotator cuff disease and bursitis: a randomized controlled trial. Arch Phys Med Rehabil 2020;Sep 11:S0003-9993(20)30923-0. Epub ahead of print.
  • Sari A, Eroglu A. Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. J Back Musculoskel Rehabil 2020;33:387-96.

EPICONDILITIS – CODO

  • Bayat M, Raeissadat SA, Mortazavian Babiki M, Rahimi-Dehgolan S. Is Dextrose Prolotherapy Superior To Corticosteroid Injection In Patients With Chronic Lateral Epicondylitis?: A Randomized Clinical Trial. Orthop Res Rev 2019;11:167-75.
  • Yelland M, Rabago D, Ryan M, Ng SK, Vithanachchi D, Manickaraj N, Bisset L. Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single-blinded randomised clinical trial. BMC Musculoskelet Disord 2019;20(509) ttps://doi.org/10.1186/s12891-019-2905-5.
  • Ahadi T, Esmaeili Jamkarani M, Raissi GR, Mansoori K, Emami Razavi SZ, Sajadi S. Prolotherapy vs radial extracorporeal shock wave therapy in the short-term treatment of lateral epicondylosis: A randomized clinical trial. Pain Med 2019;20:1745-9.

DOLOR INGUINAL y CADERA

  • Ozkan O, Torgutalp SS, Karacoban L, Donmez G, Korkusuz F. Do pain and function improve after dextrose prolotherapy or autologous platelet-rich plasma injection in longstanding groin pain? Montenegrin Journal of Sports Science and Medicine 2020;9:5-12.
  • Gul D, Orscelik A, Akpancar S. Treatment of osteoarthritis secondary to developmental dysplasia of the hip with prolotherapy injection versus a supervised progressive exercise control. Med Sci Monit 2020;26:e919166

TEMPORO-MANDIBULAR

  • Louw WF, Burrils F, Reeves KD, Cheng AL, Rabago D. Treatment of temporomandibular dysfunction with dextrose prolotherapy: A randomized controlled trial with long term follow-up Mayo Clinic Proc 2019;94:820-32.
  • Zarate MA, Frusso RD, Reeves KD, Cheng AL, Rabago D. Dextrose prolotherapy versus lidocaine injection for temporomandibular dysfunction: A pragmatic randomized controlled trial J Altern Complement Med 2020;10.1089/acm.2020.0207 Online ahead of print

CONDROMALACIA ROTULIANA

  • Orscelik A, Akpancar S, Seven MM, Erdem Y, Koca K. The efficacy of platelet rich plasma and prolotherapy in chondromalacia patella treatment. Turk J Sports Med 2020;55:28-37.

OSGOOD-SCHLATTER

  • Nakase J, Oshima T, Takata Y, Shimozaki K, Asai K, Tsuchiya H. No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double-blind study. Arch Orthop Trauma Surg 2020;140:197-202.

TOBILLO – LESIONES OCD

  • Akpancar S, Gul D. Comparison of platelet rich plasma and prolotherapy in the management of osteochondral lesions of the talus: A retrospective cohort study. Med Sci Monit 2019;25.

FASCIOPATIA PLANTAR

  • Atlas EU, Askin A, Tosun A. Is hypertonic dextrose injection effective in the treatment of plantar fasciitis: A clinical randomized study. The Medical Bulletin 2018;56:102-8.
  • Ersen O, Akpancar S, Seven MM, Akyildiz F, Yildiz Y, Ozkan H. A randomized- controlled trial of prolotherapy injections in the treatment of plantar fasciitis. Turk J Phys Med Rehab 2018;64:59-65.
  • Ugurlar M, Sonmez MM, Ugurlar OY, Adiyeke L, Yildirim H, Eren OT. Effectiveness of four different treatment modalities in the treatment of chronic plantar fasciitis during a 36-month follow-up period: A randomized controlled trial J Foot Ankle Surg; 2018; 57:913-8
  • Asheghan M, Hashemi SE, Hollisaz MT, Roumizade P, Hosseini SM, Ghanjal A. Dextrose prolotherapy versus radial extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: A randomized, controlled clinical trial. Foot Ankle Surg 2020;Aug 25:S1268-7721(20) 30176-4.
  • Mansiz-Kaplan B, Nacir B, Pervane-Vural S, Duyur-Cakit B, Genc H. Effect of dextrose prolotherapy on pain intensity, disability, and plantar fascia thickness in unilateral plantar fasciitis: A randomized, controlled, double-blind study. Am J Phys Med Rehabil 2020;99:318-24.

Células mesenquimales de la médula ósea

  • Sampson S, Botto-Van Bemden A, Aufiero D
    Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease
    The Physician and Sports Medicine. 2013 Sep
  • Jae-Do Kim, Gun Woo Lee, Gu Hee Jung, Cheung Kue Kim, Taehun Kim, Jin Hyung Park, Seong Sook Cha, Young-Bin Yoo
    Clinical Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in
  • Degenerative Arthritis of the Knee
    European journal of Orthopaedic Surgery and Traumatology. 2014 Jan
  • Hauser RA, Orlofsky A.
    Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series.
    Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4
  • Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy
    Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
    World J Orthop 2012 July 18; 3(7): 101-108
  • Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
    Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy. Knee Surg Sports Traumatol Arthrosc.
  • Goldring MB, Goldring SR
    Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis.
    Ann N Y Acad Sci 2010, 1192:230-237.
  • Buckwalter JA, Saltzman C, Brown T
    The impact of osteoarthritis: implications of research.
    Clin Orthop Relat Res 2004, (427 Suppl):S6-S15
  • Koelling S, Miosge N
    Stem cell therapy for cartilage regeneration in osteoarthritis.
    Expert Opin Biol Ther 2009, 9:1399-1405.
  • Charles J. Malemud and Victor M. Goldberg
    Future Directions for Research and Treatments of Osteoarthritis
    Frontiers in Bioscience 4, d762-771, October 15, 1999
  • Chevalier X
    Intraarticular treatments for osteoarthritis: new perspectives
    Curr Drug Targets 2010, 11:546-560.
  • Pawan K. Gupta, Anjan K. Das, Anoop Chullikana and Anish S. Majumdar
    Mesenchymal stem cells for cartilage repair in osteoarthritis.
    Stem Cell Research & Therapy 2012, 3:25 doi: 10.1186/scrt116
  • Chen FH, Tuan RS
    Mesenchymal stem cells in arthritic diseases.
    Arthritis Res Ther 2008, 10:223.
  • Niemeyer P, Krause U, Kasten P, Kreuz PC, Henle P, Sudkam NP, Mehlhorn A
    Mesenchymal stem-cell based HLA-independent cell therapy for tissue engineering of bone and cartilage.
    Curr stem Cell Res Ther 2006, 1:21-27
  • Singh A Jasvinder
    Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold?
    BMC Medicine 2012, 10:44
  • Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H
    Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees.
  • J Tissue Eng Regen Med 2007, 1:74-79
    Nejadnik H, Hui JH, Feng Choong EP, Tai B-C, Lee EH
    Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study.
    Am J Sports Med 2010, 38:1110-1116.
  • Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B
    Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients.
    Int J Rheum Dis 2011, 14:211-215.
  • Mohsen Emadedin MD, Naser Aghdmani MD PhD, Leilar Taghiyar MSc, Roghayeh Fazeli MD, Reza Moghadasali MSc, et al
    Intra-articular injection of Autologous Mesenchymal Stem Cells in Six patients with Knee Osteoarthritis
    Arch Iran Med. 2012; 15(7): 422-428.
  • Kasemkijwattana C, Hongeng S, Kesprayura S, Rungsinaporn V, Chaipinyo K, Chansiri K
    Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two case report.
    J Med Assoc Thai 2011, 94:395-400.
  • Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D
    Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
  • Pain Physician 2008, 11:343-353.
    Veronesi F, Giavaresi G, Tchon M, Borsari V, Nicoli Aldini N, Fini M.
    Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease.
    Stem Cells Dev. 2012 Nov 16. PMID: 23030230

 LESIONES DE CARTÍLAGO

  • Filardo G, Madry H, Jelic M, Roffi A, Cucchiarini M, Kon E.
    Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.
    Knee Surg Sports Traumatol Arthrosc. 2013 Jan 11.
  • Veronesi F, Giavaresi G, Tchon M, Borsari V, Nicoli Aldini N, Fini M.
    Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease.
    Stem Cells Dev. 2012 Nov 16. PMID: 23030230
  • Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy
    Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
    World J Orthop 2012 July 18; 3(7): 101-108
  • Kuroda R, Ishida K, Matsumoto T, Akisue T, Fujioka H, Mizuno K, Ohgushi H, Wakitani S, Kurosaka M
    Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells.
    Osteoarthr Cartil 2007, 15:226-231.
  • Haleem AM, Singergy AAE, Sabry D, Atta HM, Rashed LA, Chu CR, El Shewy MT, Azzam A, Abdel Aziz MT
    The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results.
    Cartilage 2010, 1:253-261.

TENDINOPATÍAS

  • Pascual-Garrido C, Rolón A, Makino A. Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup.
    Stem Cells Int. 2012;2012:953510. doi: 10.1155/2012/953510. Epub 2011 Dec 18.

 LESIONES MENISCALES

  • Duygulu F, Demirel M, Atalan G, Kaymaz FF, Kocabey Y, Dülgeroğlu TC, Candemir H.
    Effects of intra-articular administration of autologous bone marrow aspirate on healing of full-thickness meniscal tear: an experimental study on sheep.
    Acta Orthop Traumatol Turc. 2012;46(1):61-7.

LESIONES CÁPSULO-LIGAMENTOSAS

  • Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
    Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
    Knee Surg Sports Traumatol Arthrosc.

OSTEONECROSIS DE CADERA O RODILLA

  • Pak J
    Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series
    J Med Case Rep 2011, 5:296.
  • Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M.
    Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells: A pilot study
    J Bone Joint Surg Am. 2004 Jun; 86-A(6):1153-60.

 CONSOLIDACIÓN OSEA

  • Vulcano E, Murena L, Falvo DA, Baj A, Toniolo A, Cherubino P.
    Bone marrow aspirate and bone allograft to treat acetabular bone defects in revision total hip arthroplasty: preliminary report.
    Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2240-9.
  • Gessman J, Koller M, Godry H, Schildhaur T, Seyhold D, Department of General and Trauma Surgery and Department of Surgical Research, BG University Hospital
    Regenerate Augmentation with bone marrow concentrate after traumatic bone loss.
    Orthopedic Reviews 2012; volume 4:e14
  • Ph. Hernigou, MD; A. Poignard, MD; F. Beaujean, MD; H. Rouard, MD. Percutaneous Autologous Bone-Marrow Grafting for Nonunions: Influence of the Number and Concentration of Progenitor Cells. The Journal of Bone and Joint Surgery. 2005; 87:1430-1437

 ISQUEMIA DE MIEMBROS

  • Yuyama, et al
    Therapeutic Angiogenesis for Patients with Limb Ischemia by Autologous Transplantation of Bone Marrow Cells: A Pilot Study and Randomized Controlled Study
    The Lancet; 360:427-435; 2002
  • Nishimoto S, Kawai K, Tsumano T, Fukuda K, Fujiwara T, Kakibuchi M.
    Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb.
    Plast Surg Hand Surg. 2013 Apr 26.

Células mesenquimales de la grasa

RODILLA

CADERA

HOMBRO

TENDON

Orthokine

  • J Med Case Rep. 2022 May 8;16(1):183. doi: 10.1186/s13256-022-03393-9. Autologous conditioned serum (Orthokine) injection for treatment of classical trigeminal neuralgia: results of a single-center case series.
  • Aghamohammadi D(1), Sharifi S(1), Shakouri SK(2), Eslampour Y(1), Dolatkhah N(3). ANZ J Surg. 2021 Apr;91(4):673-679. doi: 10.1111/ans.16672. Epub 2021 Feb 20. Shoulder injections with autologous conditioned serum reduce pain and disability in glenohumeral osteoarthritis: longitudinal observational study.
  • Simon MJK(1)(2), Aartsen VE(2)(3), Coghlan JA(2)(4), Strahl A(1), Bell SN(2)(4). Ortop Traumatol Rehabil. 2020 Apr 30;22(2):107-119. doi: 10.5604/01.3001.0014.1167. Evaluation of the Effectiveness of Orthokine Therapy: Retrospective Analysis of 1000 Cases.
  • Godek P(1), Szajkowski S(2), Golicki D(3). Indian J Orthop. 2020 Mar 26;54(3):348-351. doi: 10.1007/s43465-020-00089-4. eCollection 2020 May. Gold-Induced Cytokine (GOLDIC(®)) Injection Therapy in Patient with Plantar Fasciosis: A Case Report.
  • Melo SNS(#)(1), Ezekwesili A(2), Yurdi NA(3), Murrell WD(#)(3)(4), Maffulli N(5)(6).
  • J Drug Assess. 2020 Mar 25;9(1):43-51. doi: 10.1080/21556660.2020.1734009. eCollection 2020. Autologous conditioned serum: clinical and functional results using a novel disease modifying agent for the management of knee osteoarthritis.
  • Vitali M(1), Ometti M(1), Drossinos A(1), Pironti P(1), Santoleri L(2), Salini V(1). Front Pharmacol. 2019 Jun 28;10:699. doi: 10.3389/fphar.2019.00699. eCollection 2019. Conditioned Serum Enhances the Chondrogenic and Immunomodulatory Behavior of Mesenchymal Stem Cells.
  • Blázquez R(1)(2), Sánchez-Margallo FM(1)(2), Reinecke J(3), Álvarez V(1), López E(1), Marinaro F(1), Casado JG(1)(2). Knee Surg Sports Traumatol Arthrosc. 2019 Sep;27(9):2744-2753. doi: 10.1007/s00167-019-05465-8. Epub 2019 Mar 21. Injection with autologous conditioned serum has better clinical results than eccentric training for chronic Achilles tendinopathy.
  • von Wehren L(1), Pokorny K(2), Blanke F(3), Sailer J(4), Majewski M(5). Med Ultrason. 2018 Aug 30;20(3):335-341. doi: 10.11152/mu-1495. The efficacy and safety of autologous conditioned serum (ACS) injections compared with betamethasone and placebo injections in the treatment of chronic shoulder joint pain due to supraspinatus tendinopathy: a prospective, randomized, double-blind, controlled study.
  • Damjanov N(1), Barac B(2), Colic J(3), Stevanovic V(4), Zekovic A(5), Tulic G(6). Sports Med Int Open. 2017 Sep 29;1(6):E200-E205. doi: 10.1055/s-0043-118625. eCollection 2017 Oct. Intra-Articular Injections of Autologous Conditioned Serum to Treat Pain from Meniscal Lesions. Strümper R(1).
  • Vet Surg. 2016 Jul;45(5):582-6. doi: 10.1111/vsu.12506. Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.
  • Sawyere DM(1), Lanz OI(1), Dahlgren LA(2), Barry SL(1), Nichols AC(2), Werre SR(3).

Hidrosecciones nerviosas

PIT

  • Effectiveness of Perineural Injections Combined with Standard Postoperative Total Knee Arthroplasty Protocols in the Management of Chronic Postsurgical Pain After Total Knee Arthroplasty.
  • Smail Güzel 1, Deniz Gül 2, Serkan Akpancar 1, John Lyftogt
  • Medical Science Monitor, February 2021. Short Term Analgesic Effects of 5% Dextrose Epidural Injections for Chronic Low Back Pain: A Randomized Controlled Trial
  • L Maniquis-Smigel, K D Reeves, H J Rosen, J Lyftogt, C Graham-Coleman, A-L Cheng,D Rabago Anesth Pain Med 2016 December 6
  • Analgesic effect and potential cumulative benefit from caudal epidural D5W in consecutive participants with chronic low back and buttock/leg pain. L Maniquis-Smigel, K D Reeves, H J Rosen, J Lyftogt, C Graham-Coleman, A-L Cheng, D Rabago
  • Journal of Alternative and Complementary Medicine Volume 00, Number 00, 2018,pp. 1–8
  • Six-month Efficacy of Perineural Dextrose for Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial
  • Y T Wu, T Ho, Y C Chou, M J Ke, T Y Li, C K Tsai, L C Chen
  • Mayo Clin Proc. 2017;92(8):1179-1189
  • Randomized double-blinded clinical trial of 5% dextrose versus triamcinolone injection for carpal tunnel syndrome patients
  • Y T Wu, M J Ke, T Y Ho, T Y Li, Y P Shen, L C Chen
  • Annals of Neurology September 2018
  • Comparison on Treatment Effects of Dextrose Water, Saline and Lidocaine for Trigger Point Injection. M Y Kim, Y M Na, J H Moon. J of Korean Acad. Of Rehab. Med. Vol 21. No 5, October 1997
  • Case Report: Dextrose Treats Optic Neuritis.  Dr Dina Soliman.
  • Journal of Medical Science and Clinical Research, Vol 06, issue 08, Page 179-183, August 2018
  • Treatment of Trigeminal Neuralgia Utilizing Neural Prolotherapy: A Case Report. Alan Itkin.  Journal of Prolotherapy. 2016;8:e961-e965

VSEL

  • Ratajczak MZ, Ratajczak J, Kucia M. Very Small Embryonic-Like Stem Cells (VSELs). Circ Res. 2019 Jan 18;124(2):208-210. doi: 10.1161/CIRCRESAHA.118.314287.
  • Deepa Bhartiya, Ambreen Shaikh, Sandhya Anand, Hiren Patel, Sona Kapoor, Kalpana Sriraman, Seema Parte, Sreepoorna Unni. Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead. Hum Reprod Update. 2016 Dec;23(1):41-76. doi: 10.1093/humupd/dmw030